Description

(3S)-4-Chloro-2,3-Dihydrobenzo[B]Furan-3-Ylamine CAS NO 1213135-36-4 is a chiral amine derivative of dihydrobenzofuran, serving as a high-value pharmaceutical intermediate and building block in organic synthesis. Its importance lies in its stereochemically defined structure, which is critical for the development of biologically active molecules with specific enantiomeric purity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in areas requiring complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and anti-inflammatory drug research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the benzofuran core and chiral center can impart specific biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in asymmetric hydrogenation and other enantioselective transformations.
• Material Science Research: Investigated as a monomer or functional component in the creation of specialty polymers and advanced organic materials.
• Academic & R&D Laboratories: Employed in methodological studies and the discovery of new synthetic routes for complex heterocyclic compounds.
• Fine Chemical Production: Utilized in the custom synthesis of complex, high-purity molecules for various industrial and research applications.

Basic Information

Product Name	(3S)-4-Chloro-2,3-Dihydrobenzo[B]Furan-3-Ylamine
CAS No.	1213135-36-4
Molecular Formula	C8H8ClNO
Molecular Weight	169.61 g/mol
Synonyms	(3S)-4-Chloro-2,3-dihydro-1-benzofuran-3-amine; (3S)-4-Chloro-2,3-dihydrobenzofuran-3-amine; 4-Chloro-2,3-dihydrobenzofuran-3-amine (S-enantiomer); (S)-4-Chloro-2,3-dihydrobenzo[b]furan-3-amine; 1213135-36-4; Benzenamine, 4-chloro-2,3-dihydro-3-(S)-3-benzofuranyl-; (S)-4-Chloro-2,3-dihydro-1-benzofuran-3-amine
EINECS	Contact for details

Quality Control

Our (3S)-4-Chloro-2,3-Dihydrobenzo[B]Furan-3-Ylamine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure high chemical and optical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.