Description

(1S)-2,2-Dimethyl-1-(2-Thienyl)Propylamine CAS NO 1212849-69-8 is a high-purity chiral amine building block characterized by its thiophene and tert-butylamine moieties. This compound is a critical intermediate in the synthesis of advanced pharmaceutical active ingredients, particularly for chiral drugs targeting the central nervous system. It is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries who require a reliable source of enantiomerically pure intermediates.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel therapeutic agents, especially in neurology and psychiatry.
• Asymmetric Synthesis: Used as a ligand precursor or chiral auxiliary in catalytic asymmetric reactions to induce stereoselectivity.
• Agrochemical Research: Intermediate in the development of new, enantiomerically pure pesticides and herbicides.
• Material Science: Potential monomer or additive for creating specialized polymers with unique electronic properties derived from the thiophene unit.
• Academic & Industrial R&D: Serves as a standard or starting material for methodological development in organic and medicinal chemistry.
• Process Chemistry: Scalable intermediate for the commercial production of patented drug substances under cGMP conditions.

Basic Information

Product Name	(1S)-2,2-Dimethyl-1-(2-Thienyl)Propylamine
CAS No.	1212849-69-8
Molecular Formula	C9H15NS
Molecular Weight	169.29 g/mol
Synonyms	(S)-2,2-Dimethyl-1-(thiophen-2-yl)propan-1-amine; (1S)-1-(2-Thienyl)-2,2-dimethylpropylamine; (S)-α-(2,2-Dimethylpropyl)thiophene-2-methanamine; (S)-tert-Butyl(thiophen-2-yl)methylamine; (S)-2-Thienyl-tert-butylmethylamine; (S)-Amino(tert-butyl)(2-thienyl)methane; (S)-1-(Thiophen-2-yl)-2,2-dimethylpropylamine
EINECS	Contact for details

Quality Control

Our (1S)-2,2-Dimethyl-1-(2-Thienyl)Propylamine is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including chiral HPLC to ensure high enantiomeric excess (ee) and identity confirmation by NMR and IR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing purity, assay, and impurity profiles. Production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.