Description

3-(Exo-9-Fluorenylmethoxycarbonylamino)Bicyclo[2.2.1]Hept-5-Ene-2-Exo-Carboxylic Acid is a specialized, high-purity building block designed for advanced organic synthesis. This compound matters for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. Professionals in medicinal chemistry and process development need it for constructing novel drug candidates, especially those utilizing the Fmoc-protected amine functionality for peptide and peptidomimetic synthesis. Its unique bicyclic structure offers valuable stereochemical control for creating constrained architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates.
• Peptidomimetic Research: Used to incorporate constrained, bicyclic amino acid analogs into peptide chains to enhance metabolic stability and binding affinity.
• Medicinal Chemistry: Serves as a versatile scaffold in structure-activity relationship (SAR) studies and the development of new therapeutic agents.
• Process Chemistry: Employed in the development and scale-up of synthetic routes for complex organic molecules under cGMP conditions where applicable.
• Bioconjugation: The carboxylic acid moiety allows for further functionalization and conjugation to other molecules or solid supports.
• Academic & Institutional Research: Used in universities and research institutes for pioneering studies in organic synthesis and chemical biology.

Basic Information

Product Name	3-(Exo-9-Fluorenylmethoxycarbonylamino)Bicyclo[2.2.1]Hept-5-Ene-2-Exo-Carboxylic Acid
CAS No.	1212223-66-9
Molecular Formula	C24H23NO4
Molecular Weight	389.45 g/mol
Synonyms	Fmoc-5-Norbornene-2-exo-carboxylic Acid; 5-Norbornene-2-exo-carboxylic Acid, 3-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-; 3-[(Fmoc)amino]bicyclo[2.2.1]hept-5-ene-2-carboxylic Acid; 3-(Fmoc-amino)-5-norbornene-2-exo-carboxylic Acid; 3-(9-Fluorenylmethoxycarbonylamino)bicyclo[2.2.1]hept-5-ene-2-carboxylic Acid; 3-(N-Fmoc-amino)-2-norbornene-5-carboxylic Acid; Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-
EINECS	Contact for details

Quality Control

Our 3-(Exo-9-Fluorenylmethoxycarbonylamino)Bicyclo[2.2.1]Hept-5-Ene-2-Exo-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and chiral analysis to ensure stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.