Description

N5-Carbamoyl-N2-[(4-Chloro-1H-Indol-1-Yl)Acetyl]-D-Ornithine is a specialized, non-proteinogenic amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound matters as a key chiral building block or intermediate for the synthesis of complex bioactive molecules, particularly those targeting specific enzymatic pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents, including protease inhibitors and other peptidomimetic drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of potential drug candidates, especially those with indole-based pharmacophores.
• Protease Inhibitor Research: Used in the design and development of novel inhibitors for enzymes like serine or cysteine proteases, owing to its ornithine-derived structure.
• Peptidomimetic Development: Acts as a building block for creating peptidomimetics—molecules that mimic peptides but with enhanced stability and bioavailability.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds or activity-based probes for studying enzyme function and mechanism in biological systems.
• Academic & Contract Research: Employed in university laboratories and CROs (Contract Research Organizations) for exploratory medicinal chemistry projects.
• Process Chemistry & Scale-Up: Investigated for use in the optimization and scale-up of synthetic routes for active pharmaceutical ingredients (APIs) under GMP-like conditions.

Basic Information

Product Name	N5-Carbamoyl-N2-[(4-Chloro-1H-Indol-1-Yl)Acetyl]-D-Ornithine
CAS No.	1212136-76-9
Molecular Formula	C16H19ClN4O4
Molecular Weight	366.80 g/mol
Synonyms	D-Ornithine, N5-carbamoyl-N2-[(4-chloro-1H-indol-1-yl)acetyl]-; (2R)-5-Carbamoylamino-2-[[(4-chloro-1H-indol-1-yl)acetyl]amino]pentanoic acid; 4-Chloro-1H-indole-1-acetic acid D-ornithine amide (N5-carbamoyl); Nα-[(4-Chloro-1H-indol-1-yl)acetyl]-Nδ-carbamoyl-D-ornithine; (R)-2-((4-Chloro-1H-indol-1-yl)acetamido)-5-ureidopentanoic acid; A building block for protease inhibitors; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our N5-Carbamoyl-N2-[(4-Chloro-1H-Indol-1-Yl)Acetyl]-D-Ornithine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and chiral analysis to confirm enantiomeric excess. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (D-isomer)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.