Description

(R)-2-(tert-Butoxycarbonyl)Isoindoline-1-Carboxylic Acid CAS NO 1212086-74-2 is a high-purity, chiral isoindoline derivative that serves as a critical building block in modern organic synthesis. Its primary value lies in its role as a protected intermediate for constructing complex pharmaceutical molecules, particularly those requiring precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries who are developing new active ingredients, such as protease inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, especially in protease inhibitor research.
• Agrochemical Synthesis: Used in the development of enantiomerically pure active ingredients for crop protection products.
• Peptidomimetics: Serves as a constrained scaffold in the design of peptide mimics to improve metabolic stability and bioavailability.
• Asymmetric Catalysis Ligand Precursor: Potential starting material for synthesizing chiral ligands used in asymmetric hydrogenation and other catalytic transformations.
• Chemical Biology Probes: Utilized in the creation of tagged or modified molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API (Active Pharmaceutical Ingredient) synthesis projects.

Basic Information

Product Name	(R)-2-(tert-Butoxycarbonyl)Isoindoline-1-Carboxylic Acid
CAS No.	1212086-74-2
Molecular Formula	C14H17NO4
Molecular Weight	263.29 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-2-carboxy-(R)-isoindoline; (R)-1,2,3,4-Tetrahydro-1-isoindolecarboxylic acid, 2-[(1,1-dimethylethoxy)carbonyl]-, (R)-; (R)-2-[(tert-Butoxycarbonyl)amino]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (common misassignment check); Boc-(R)-Isoindoline-1-Carboxylic Acid; (R)-Boc-Isoindoline-1-Carboxylic Acid; (2R)-2-[(tert-Butoxycarbonyl)]-2,3-dihydro-1H-isoindole-1-carboxylic acid; 1212086-74-2
EINECS	Contact for details

Quality Control

Every batch of (R)-2-(tert-Butoxycarbonyl)Isoindoline-1-Carboxylic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity compliant with industry standards for advanced intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.