Description

5-Phenyl-2-(Trifluoromethyl)-1H-Indole-7-Carboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique indole core structure. This compound matters for its critical role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry. Pharmaceutical R&D teams and fine chemical manufacturers need it to develop new drug candidates targeting a range of therapeutic areas, where its specific trifluoromethyl and carboxamide functionalities are essential for modulating potency and pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: A crucial precursor in the research and development of new active pharmaceutical ingredients (APIs), especially for oncology and central nervous system (CNS) drug candidates.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Used in academic and industrial laboratories to study enzyme inhibition and receptor-ligand interactions.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to construct complex heterocyclic compounds for advanced material science applications.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of investigational new drugs.

Basic Information

Item	Details
Product Name	5-Phenyl-2-(Trifluoromethyl)-1H-Indole-7-Carboxamide
CAS No.	1211597-10-2
Molecular Formula	C₁₆H₁₁F₃N₂O
Molecular Weight	304.27 g/mol
Synonyms	5-Phenyl-2-(trifluoromethyl)-1H-indole-7-carboxamide; 7-Carbamoyl-5-phenyl-2-(trifluoromethyl)indole; 1H-Indole-7-carboxamide, 5-phenyl-2-(trifluoromethyl)-; 5-Phenyl-2-trifluoromethyl-1H-indole-7-carboxylic acid amide; 1211597-10-2
EINECS	Contact for details

Quality Control

Our 5-Phenyl-2-(Trifluoromethyl)-1H-Indole-7-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are available upon request for full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.