Description

2-Bromo-4H-Pyrrolo[3,4-D]Thiazol-6(5H)-One is a high-value brominated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile and critical precursor for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process R&D, and the synthesis of new chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the bromo-thiazolopyrrolone moiety.
• Chemical Synthesis: Serves as a versatile electrophilic building block for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitutions.
• Agrochemical Research: Potential intermediate in the synthesis of novel herbicides or fungicides with specific biological activity.
• Material Science: Exploration of its use in creating organic electronic materials or functional dyes due to its fused heterocyclic structure.
• Contract Research & Manufacturing (CRO/CMO): Supplied for custom synthesis projects and scale-up processes under cGMP conditions where required.

Basic Information

Product Name	2-Bromo-4H-Pyrrolo[3,4-D]Thiazol-6(5H)-One
CAS No.	1211531-11-1
Molecular Formula	C6H3BrN2OS
Molecular Weight	231.07 g/mol
Synonyms	2-Bromo-4H-pyrrolo[3,4-d]thiazol-6(5H)-one; 2-Bromo-5,6-dihydro-4H-pyrrolo[3,4-d]thiazol-6-one; 2-Bromothiazolo[5,4-c]pyrrol-4(5H)-one; 1211531-11-1; Brominated thiazolopyrrolone; 2-Bromo-4H,5H,6H-pyrrolo[3,4-d]thiazol-6-one
EINECS	Contact for details

Quality Control

Our 2-Bromo-4H-Pyrrolo[3,4-D]Thiazol-6(5H)-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided for every shipment. We support development and commercial projects with material suitable for research use and can supply grades aligned with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere if specified for high-purity grades. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (HPLC)	≥ 98.0% / ≥ 99.0% (High Purity Grades)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.