Description

4-(Trifluoromethyl)Indoline Hydrochloride is a high-purity, fluorinated indoline derivative used as a critical building block in advanced organic synthesis. This compound is valued for its trifluoromethyl group, which imparts unique physicochemical properties essential for modulating the biological activity and metabolic stability of target molecules. It is primarily sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new therapeutic agents, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Serves as a precursor in the creation of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological efficacy.
• Material Science Research: Used in the synthesis of specialty chemicals and advanced materials, such as organic semiconductors or liquid crystals, where fluorine substitution is beneficial.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	4-(Trifluoromethyl)Indoline Hydrochloride
CAS No.	1209980-57-3
Molecular Formula	C9H9ClF3N
Molecular Weight	223.62 g/mol
Synonyms	4-(Trifluoromethyl)-2,3-dihydro-1H-indole hydrochloride; 1H-Indole, 2,3-dihydro-4-(trifluoromethyl)-, hydrochloride; Indoline, 4-(trifluoromethyl)-, hydrochloride; 4-Trifluoromethylindoline HCl
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Indoline Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.