Description

(1S)-2,2,2-Trifluoro-1-(3-Thienyl)Ethylamine is a high-purity chiral amine building block featuring a trifluoroethyl group attached to a thiophene ring. This compound is a critical intermediate in modern pharmaceutical and agrochemical research, valued for its ability to impart metabolic stability and modulate physicochemical properties in active molecules. It is primarily sought by R&D chemists and process development scientists in the life sciences sector for the synthesis of novel therapeutic candidates and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the trifluoromethyl group enhances biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers for advanced electronic or optical materials.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research focused on introducing fluorine atoms into complex molecular architectures.

Basic Information

Product Name	(1S)-2,2,2-Trifluoro-1-(3-Thienyl)Ethylamine
CAS No.	1209050-27-0
Molecular Formula	C6H6F3NS
Molecular Weight	181.18 g/mol
Synonyms	(S)-1-(Thiophen-3-yl)-2,2,2-trifluoroethanamine; (S)-α-(Trifluoromethyl)thiophene-3-methanamine; (1S)-1-(3-Thienyl)-2,2,2-trifluoroethylamine; (S)-3-(Aminomethyl)-α,α,α-trifluorothiophene; (S)-TFMA; (S)-Trifluoro(thiophen-3-yl)methylamine; (S)-1-(3-Thienyl)-2,2,2-trifluoroethan-1-amine
EINECS	Contact for details

Quality Control

Every batch of (1S)-2,2,2-Trifluoro-1-(3-Thienyl)Ethylamine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity compliant with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.