Description

Oclacitinib Maleate (PF-03394197) is a potent and selective Janus kinase (JAK) inhibitor, specifically targeting JAK1-dependent cytokines involved in allergic and pruritic pathways. This makes it a critical active pharmaceutical ingredient (API) for the development of targeted veterinary therapeutics. It is primarily sought by pharmaceutical manufacturers and research institutions focused on developing advanced treatments for canine atopic dermatitis and other inflammatory conditions in animals. The compound is supplied under strict quality control to ensure consistency for formulation and research applications.

Application

• Veterinary Pharmaceutical API: Primary use as the active ingredient in oral tablets (e.g., Apoquel®) for the control of pruritus and atopic dermatitis in dogs.
• Veterinary Drug Development: Key intermediate for research and development of new JAK inhibitor-based therapies for companion animals.
• Comparative Medical Research: Used in preclinical studies to understand JAK/STAT signaling pathways relevant to both veterinary and human immunology.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control laboratories in pharmaceutical manufacturing.
• Biochemical Research: A tool compound for in vitro studies investigating the role of specific JAK isoforms in cellular signaling and inflammation.

Basic Information

Product Name	Oclacitinib Maleate (PF-03394197)
CAS No.	1208319-27-0
Molecular Formula	C16H19N5O2 • C4H4O4
Molecular Weight	441.43 g/mol
Synonyms	PF-03394197; Oclacitinib Maleate; Apoquel (brand name basis); (3S,4R)-4-(3-(Cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-3-ethyl-1-(2-hydroxy-2-methylpropyl)-1H-pyrazolo[3,4-c]pyridin-6(5H)-one maleate; Janus Kinase 1 Inhibitor; JAK1 Inhibitor
EINECS	Contact for details

Quality Control

Our Oclacitinib Maleate is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material compliant with current industry standards for API manufacturing. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.