Description

Oclacitinib is a potent and selective Janus kinase (JAK) inhibitor, specifically targeting JAK1-dependent cytokines involved in allergic and inflammatory pathways. This targeted mechanism makes it a critical active pharmaceutical ingredient (API) for the development of veterinary therapeutics. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on veterinary medicine, particularly for the treatment of canine atopic dermatitis and other pruritic conditions.

Application

• Veterinary Pharmaceutical API: Primary active ingredient in oral tablets for the control of pruritus associated with allergic dermatitis in dogs.
• Veterinary Dermatology Research: Key compound for preclinical and clinical studies investigating JAK-mediated inflammatory pathways in companion animals.
• Pharmaceutical Intermediates: Serves as a high-purity intermediate for the synthesis of finished dosage forms in GMP-compliant manufacturing facilities.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for quality control and method validation of veterinary drug products.
• Formulation Development: Employed in R&D for developing novel delivery systems, such as chewable tablets or topical formulations, to enhance efficacy and palatability.

Basic Information

Product Name	Oclacitinib
CAS No.	1208319-26-9
Molecular Formula	C16H21N5O3S
Molecular Weight	363.44 g/mol
Synonyms	PF-03394197; Apoquel (brand name); (3S)-3-[4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-cyclopentylpropanenitrile; 3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile; JAK1 Inhibitor; Janus Kinase 1 Inhibitor
EINECS	Contact for details

Quality Control

Our Oclacitinib is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical actives. Quality is assured through comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with each batch, confirming compliance with agreed specifications. We support development and commercial projects requiring adherence to GMP, ICH Q7, and relevant veterinary pharmacopoeia guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.