Description

1-Bromo-3,4-difluoro-2-iodobenzene is a highly functionalized halogenated benzene derivative, serving as a critical multi-halogen synthon in advanced organic synthesis. Its precise substitution pattern makes it an invaluable building block for constructing complex molecules where regiochemical control is paramount. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides that benefit from the stability and lipophilicity imparted by fluorine and iodine atoms.
• Material Science Research: Used in the development of organic electronic materials, such as OLEDs and semiconductors, where halogen atoms facilitate cross-coupling reactions.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Chemical Biology Probes: Employed in the creation of molecular probes and tags for studying biological systems, leveraging iodine for potential radiolabeling.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring specific halogenated aromatic cores.

Basic Information

Product Name	1-Bromo-3,4-difluoro-2-iodobenzene
CAS No.	1208077-27-3
Molecular Formula	C6H2BrF2I
Molecular Weight	318.89 g/mol
Synonyms	2-Bromo-1,2-difluoro-3-iodobenzene; 3,4-Difluoro-2-iodo-1-bromobenzene; 1-Bromo-3,4-difluoro-2-iodo-benzene; Benzene, 1-bromo-3,4-difluoro-2-iodo-; 2-Iodo-3,4-difluorobromobenzene; 3,4-Difluoro-2-iodophenyl bromide
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-3,4-difluoro-2-iodobenzene is manufactured and analyzed under strict quality management protocols to ensure consistency and purity for sensitive synthetic applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request for quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.