Description

[2H3]-1,4-Dihydro-1-Methyl-4-Oxo-3-Pyridinecarboxamide is a deuterated analog of a key pyridinecarboxamide derivative, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is essential for advanced analytical research, providing a critical internal standard for precise quantification and metabolic pathway tracing. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and contract research organizations (CROs) engaged in drug development and bioanalytical studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the accurate quantification of its non-deuterated counterpart in complex biological matrices using mass spectrometry.
• Metabolic Studies: Used in pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) research to track and differentiate drug metabolites from endogenous compounds.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products during drug substance development.
• Deuterium-Labeled Probe Synthesis: Acts as a building block for synthesizing more complex deuterated molecules used in mechanistic and structural elucidation studies.
• Bioanalytical Method Development: Enables the validation of highly sensitive and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).

Basic Information

Product Name	[2H3]-1,4-Dihydro-1-Methyl-4-Oxo-3-Pyridinecarboxamide
CAS No.	1207384-47-1
Molecular Formula	C8H6D3N2O2
Molecular Weight	168.18 g/mol
Synonyms	Deuterated Dihydropyridinecarboxamide; 1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide-d3; 3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-4-oxo-, 2,5,6-d3-; 1-Methyl-4-oxo-1,4-dihydropyridine-3-carboxamide-d3; [2,5,6-2H3]-1-Methyl-4-oxo-1,4-dihydro-3-pyridinecarboxamide; 1,4-Dihydro-1-methyl-4-oxonicotinamide-d3; Deuterium Labeled DHP Derivative
EINECS	Contact for details

Quality Control

Every batch of [2H3]-1,4-Dihydro-1-Methyl-4-Oxo-3-Pyridinecarboxamide is produced and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including assay, isotopic enrichment (D%), and identification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with customer specifications and industry best practices for stable isotope-labeled compounds.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product under inert atmosphere to ensure optimal stability of the deuterium label and chemical integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.