Description

2,2,2-Trifluoro-1-(Thiophen-3-Yl)Ethanamine is a high-value fluorinated building block containing both a thiophene ring and a trifluoroethylamine moiety. This compound matters for its unique structural features, which are critical for modulating the physicochemical and biological properties of advanced molecules in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients. The compound is supplied to exacting standards to ensure reliable performance in sensitive synthetic applications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the fluorine atoms enhance bioavailability and metabolic stability.
• Material Science: Serves as a precursor for specialty polymers and advanced organic electronic materials due to the electron-rich thiophene unit.
• Ligand Synthesis: Employed in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry: A versatile reagent for introducing the trifluoroethylamine pharmacophore into target molecules.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring this specialized scaffold.

Basic Information

Product Name	2,2,2-Trifluoro-1-(Thiophen-3-Yl)Ethanamine
CAS No.	1207175-66-3
Molecular Formula	C6H6F3NS
Molecular Weight	181.18 g/mol
Synonyms	3-(2,2,2-Trifluoroethylamino)thiophene; 1-(3-Thienyl)-2,2,2-trifluoroethanamine; 2,2,2-Trifluoro-1-(3-thienyl)ethanamine; α-(Trifluoromethyl)-3-thiophenemethylamine; 3-Thiophene(trifluoroethyl)amine; 1-(Thiophen-3-yl)-2,2,2-trifluoroethan-1-amine; TTE-Thiophene
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(Thiophen-3-Yl)Ethanamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports applications requiring high-purity intermediates under GMP or ISO-guided conditions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.