Description

(R)-tert-Butyl 1-(Aminomethyl)-3,4-Dihydroisoquinoline-2(1H)-Carboxylate CAS NO 1207175-15-2 is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is of significant value for the synthesis of complex bioactive molecules, particularly in the development of central nervous system (CNS) and cardiovascular therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, process development, and the manufacture of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates targeting neurological and cardiovascular disorders.
• Asymmetric Synthesis: Serves as a versatile building block for constructing complex, enantiomerically pure molecules in medicinal chemistry.
• Process Chemistry: Used in the development and scale-up of synthetic routes for Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Research & Development: Essential for academic and industrial research focused on isoquinoline-based chemistry and pharmacology.
• Chemical Biology: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis: A starting material for the contract manufacturing of specialized fine chemicals and bespoke intermediates.

Basic Information

Product Name	(R)-tert-Butyl 1-(Aminomethyl)-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	1207175-15-2
Molecular Formula	C16H22N2O2
Molecular Weight	274.36 g/mol
Synonyms	(R)-1,2,3,4-Tetrahydro-1-(aminomethyl)isoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl (R)-1-(aminomethyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; (R)-1-(Aminomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylic acid tert-butyl ester; (R)-N-Boc-1-(aminomethyl)-1,2,3,4-tetrahydroisoquinoline; Boc-(R)-1-(Aminomethyl)-1,2,3,4-tetrahydroisoquinoline; (R)-tert-Butyl 1-(aminomethyl)-3,4-dihydro-2H-isoquinoline-2-carboxylate; 1207175-15-2
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 1-(Aminomethyl)-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to meet the stringent requirements of pharmaceutical development. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing identity, purity, and impurity profiles. We support development from research to commercial scale with quality standards aligned with cGMP principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.