Description

6-Bromo-2-(Tetrahydro-2H-Pyran-2-Yl)-2H-Indazol-5-Ol is a high-purity, advanced pharmaceutical intermediate featuring a brominated indazole core protected by a tetrahydropyranyl (THP) group. This compound is of significant value for its role as a key building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing novel therapeutic agents, such as kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of targeted drug candidates, especially in oncology and anti-inflammatory research.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Kinase Inhibitor Development: A key fragment in the construction of potent and selective kinase inhibitors due to its indazole pharmacophore.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and clinical trial materials.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying specific biological pathways and target validation.
• Academic Research: Employed in university and institutional labs for exploratory synthetic chemistry and novel heterocycle development.

Basic Information

Product Name	6-Bromo-2-(Tetrahydro-2H-Pyran-2-Yl)-2H-Indazol-5-Ol
CAS No.	1206800-27-2
Molecular Formula	C₁₂H₁₃BrN₂O₂
Molecular Weight	297.15 g/mol
Synonyms	6-Bromo-2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-5-ol; 5-Indazolol, 6-bromo-2-(tetrahydro-2H-pyran-2-yl)-; 6-Bromo-2-(THP)-2H-indazol-5-ol; 6-Bromo-2-(tetrahydropyran-2-yl)-1H-indazol-5-ol; 1206800-27-2; 6-Bromo-2-(oxan-2-yl)-2H-indazol-5-ol; 6-Bromo-2-(2H-pyran-2-yl-tetrahydro)-2H-indazol-5-ol
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-(Tetrahydro-2H-Pyran-2-Yl)-2H-Indazol-5-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports compliance with the standards required for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.