Description

Ethyl 2-Amino-1-(5-Chlorobenzo[B]Thiophen-3-Yl)-2-Oxoethyl(Methyl)Phosphinate is a specialized organophosphorus compound featuring a benzothiophene core, designed for advanced chemical synthesis and pharmaceutical research. This high-purity intermediate is critical for developing novel active pharmaceutical ingredients (APIs) and agrochemicals, offering precise molecular architecture for targeted applications. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to build complex heterocyclic structures.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing kinase inhibitory activity.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, or insecticides, leveraging its unique chlorinated benzothiophene moiety.
• Chemical Biology Probe: Acts as a precursor for creating molecular probes to study enzyme function or biological pathways due to its phosphinate group and reactive sites.
• Material Science Research: Investigated as a monomer or additive for creating specialized polymers with specific thermal or optical properties.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of complex target molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring this precise chemical scaffold.

Basic Information

Product Name	Ethyl 2-Amino-1-(5-Chlorobenzo[B]Thiophen-3-Yl)-2-Oxoethyl(Methyl)Phosphinate
CAS No.	1206680-28-5
Molecular Formula	C15H17ClNO3PS
Molecular Weight	357.79 g/mol
Synonyms	Ethyl (2-Amino-1-(5-chlorobenzo[b]thiophen-3-yl)-2-oxoethyl)(methyl)phosphinate; (2-Amino-1-(5-chlorobenzo[b]thiophen-3-yl)-2-oxoethyl)(methyl)phosphinic Acid Ethyl Ester; 5-Chloro-3-[(1-amino-2-ethoxy(methyl)phosphinyl)acetyl]-1-benzothiophene; Methyl(ethyl) 2-amino-1-(5-chlorobenzo[b]thien-3-yl)-2-oxoethylphosphonate; CAS 1206680-28-5
EINECS	Contact for details

Quality Control

Every batch of Ethyl 2-Amino-1-(5-Chlorobenzo[B]Thiophen-3-Yl)-2-Oxoethyl(Methyl)Phosphinate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any Single Unknown Impurity	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.