Description

1-(Methylsulfonyl)-4-[[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl]Piperazine is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl scaffolds. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel small-molecule therapeutics, particularly in oncology and CNS disease areas.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aromatic rings, essential for creating diverse chemical libraries.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a critical raw material in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Bioconjugation & Probe Synthesis: Potential use in creating labeled compounds or molecular probes for biochemical and diagnostic applications.
• Material Science Precursor: Can be employed in the synthesis of organic electronic materials or metal-organic frameworks (MOFs).

Basic Information

Product Name	1-(Methylsulfonyl)-4-[[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl]Piperazine
CAS No.	1206641-59-9
Molecular Formula	C18H29BN2O4S
Molecular Weight	380.31 g/mol
Synonyms	4-[(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-1-(methylsulfonyl)piperazine; 1-Methanesulfonyl-4-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]piperazine; 4-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)(methylsulfonyl)amino)piperidine (related structure); Boric acid, cyclic ester with 1-(methylsulfonyl)-4-[[4-(hydroxyboranyl)phenyl]methyl]piperazine; PINAP-Boronate derivative; Suzuki Coupling Boronate Ester.
EINECS	Contact for details

Quality Control

Our 1-(Methylsulfonyl)-4-[[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl]Piperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive coupling reactions. All batches are supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques (HPLC, NMR, LC-MS). We adhere to cGMP guidelines where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.