Description

6-(Difluoromethyl)Isoquinoline is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the difluoromethyl group, which is a key motif in modern medicinal and agrochemical design. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, as well as by manufacturers of specialty chemicals and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance bioavailability and metabolic stability.
• Material Science: Serves as a precursor for functionalized ligands and organic frameworks used in catalysis and advanced polymeric materials.
• Chemical Synthesis: Acts as a versatile synthon for introducing the isoquinoline scaffold with a fluorinated handle for further derivatization via cross-coupling or functional group transformations.
• Fluorine Chemistry Research: An important compound for studying the effects of fluorination on the electronic and steric properties of heterocyclic systems.

Basic Information

Product Name	6-(Difluoromethyl)Isoquinoline
CAS No.	1204298-75-8
Molecular Formula	C₁₀H₇F₂N
Molecular Weight	179.17 g/mol
Synonyms	6-(Difluoromethyl)isoquinoline; Isoquinoline, 6-(difluoromethyl)-; 6-Difluoromethylisoquinoline; 1204298-75-8; 6-(Difluoromethyl)-isoquinoline; 6-(Difluoromethyl)isoquinoline, 97%; 6-(Difluoromethyl)isoquinoline, 95%
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethyl)Isoquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters. Our commitment is to supply material that meets the exacting standards required for research and commercial-scale synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.