Description

8-(Difluoromethyl)Isoquinoline is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its unique structure, featuring a difluoromethyl group on the isoquinoline core, makes it a critical intermediate for developing novel compounds with tailored properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for introducing fluorine atoms to modulate bioavailability and metabolic stability.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance biological activity and environmental persistence.
• Material Science Precursor: Acts as a building block for creating specialized fluorinated polymers, liquid crystals, or organic electronic materials with unique optical or electrical properties.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and hit-to-lead optimization campaigns to explore new chemical space in drug discovery.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research focused on developing new fluorination methodologies and understanding fluorine's effects in molecular systems.
• Ligand and Catalyst Development: Can be utilized to synthesize novel chelating ligands or organocatalysts for asymmetric synthesis and transition metal catalysis.

Basic Information

Product Name	8-(Difluoromethyl)Isoquinoline
CAS No.	1204298-62-3
Molecular Formula	C₁₁H₇F₂N
Molecular Weight	191.18 g/mol
Synonyms	8-(Difluoromethyl)isoquinoline; Isoquinoline, 8-(difluoromethyl)-; 8-Difluoromethylisoquinoline; 1204298-62-3; 8-(Difluoromethyl)-isoquinoline; 8-(Difluoromethyl)isoquinoline (CAS 1204298-62-3); 8-(Difluoromethyl)isoquinoline, 97% min; 8-(Difluoromethyl)-1-azanaphthalene
EINECS	Contact for details

Quality Control

Our 8-(Difluoromethyl)Isoquinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our customers' regulatory requirements in advanced research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.