Description

5-(Difluoromethyl)Isoquinoline is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the difluoromethyl group, which is a key motif for modulating the biological activity and metabolic stability of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting kinases and other enzymes.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance efficacy and environmental profile.
• Material Science Precursor: Serves as a specialty monomer or ligand precursor for creating advanced polymers, metal-organic frameworks (MOFs), or functional materials.
• Fluorine Chemistry & Methodology Development: An important substrate for academic and industrial research into new fluorination reactions and C-H functionalization techniques.
• Ligand Synthesis for Catalysis: Used to construct complex nitrogen-containing ligands for asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	5-(Difluoromethyl)Isoquinoline
CAS No.	1204298-57-6
Molecular Formula	C10H7F2N
Molecular Weight	179.17 g/mol
Synonyms	Isoquinoline, 5-(difluoromethyl)-; 5-Difluoromethylisoquinoline; 1204298-57-6; 5-(Difluoromethyl)isoquinoline; 5-(Difluoromethyl)-isoquinoline
EINECS	Contact for details

Quality Control

Our 5-(Difluoromethyl)Isoquinoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.