Description

5-(Difluoromethyl)-1H-Indazole is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core indazole scaffold, functionalized with a difluoromethyl group, makes it a critical intermediate for developing novel pharmaceuticals and agrochemicals. This compound is primarily utilized by research and development chemists in the pharmaceutical industry for creating new drug candidates, particularly in areas such as kinase inhibition and oncology.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and targeted cancer therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging the biological activity of the indazole core and fluorine atoms.
• Material Science: Serves as a precursor for advanced organic materials, including liquid crystals and organic light-emitting diodes (OLEDs).
• Chemical Biology: Employed as a molecular probe or tag in medicinal chemistry and biochemical research to study enzyme interactions.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects and library production for high-throughput screening.

Basic Information

Product Name	5-(Difluoromethyl)-1H-Indazole
CAS No.	1204298-50-9
Molecular Formula	C8H6F2N2
Molecular Weight	168.14 g/mol
Synonyms	5-(Difluoromethyl)-1H-indazole; 1H-Indazole, 5-(difluoromethyl)-; 5-(Difluoromethyl)indazole; 5-Difluoromethyl-1H-indazole; 1204298-50-9; 5-(Difluoromethyl)indazole; Difluoromethyl-indazole
EINECS	Contact for details

Quality Control

Our 5-(Difluoromethyl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.