Description

Methyl 4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylate Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a defined molecular structure, essential for modern synthetic chemistry. Its primary value lies in serving as a critical building block for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and neurological disorder therapeutics. This compound is specifically needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and academic institutions engaged in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, particularly those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• API Development: Serves as a core scaffold for the development of novel Active Pharmaceutical Ingredients (APIs), especially in the fields of antidepressants, antipsychotics, and neuroprotective agents.
• Contract Manufacturing: Supplied to CROs and CDMOs for process development, scale-up, and cGMP manufacturing of clinical trial materials.
• Academic & Institutional Research: Utilized in university and institutional labs for fundamental research in organic synthesis and pharmacology.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	Methyl 4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylate Hydrochloride
CAS No.	1203686-89-8
Molecular Formula	C13H17NO2 · HCl
Molecular Weight	255.74 g/mol
Synonyms	8-Methoxycarbonyl-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; Methyl 4,4-dimethyl-3,4-dihydro-1H-isoquinoline-8-carboxylate hydrochloride; 4,4-Dimethyl-1,2,3,4-tetrahydroisoquinoline-8-carboxylic acid methyl ester hydrochloride; 4,4-Dimethyl-1,2,3,4-tetrahydro-8-isoquinolinecarboxylic acid methyl ester hydrochloride; 8-(Methoxycarbonyl)-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline HCl; 4,4-Dimethyl-THIQ-8-COOMe · HCl
EINECS	Contact for details

Quality Control

Our Methyl 4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylate Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. While produced to meet exacting internal standards, specifications can be aligned with client requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.