Description

4,4-Dimethyl-7-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring a tetrahydroisoquinoline scaffold with a trifluoromethyl group, makes it a critical intermediate for developing novel bioactive molecules. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for applications in medicinal chemistry and crop protection science.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Serves as a building block for creating novel pesticides and herbicides with enhanced efficacy and environmental profiles.
• Material Science Research: Used in the development of specialty chemicals and advanced materials, including liquid crystals and organic semiconductors.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization due to its unique fluorine-substituted heterocyclic core.
• Chemical Biology: Utilized as a probe or ligand scaffold in biochemical assay development and target identification.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring fluorinated isoquinoline derivatives.

Basic Information

Product Name	4,4-Dimethyl-7-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1203686-61-6
Molecular Formula	C12H14F3N
Molecular Weight	229.24 g/mol
Synonyms	7-(Trifluoromethyl)-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline; 4,4-Dimethyl-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-4,4-dimethyl-7-(trifluoromethyl)isoquinoline; 4,4-Dimethyl-7-(trifluoromethyl)-3,4-dihydro-1H-isoquinoline; DTFTIQ; CAS 1203686-61-6
EINECS	Contact for details

Quality Control

Our 4,4-Dimethyl-7-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment. We support development projects with custom purity grades and analytical method support upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.