Description

5-Fluoro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline is a high-purity, fluorinated tetrahydroisoquinoline derivative, a privileged scaffold in medicinal chemistry. This compound matters as a critical advanced pharmaceutical intermediate for the research and development of novel therapeutic agents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to the bioactive tetrahydroisoquinoline core.
• Agrochemical Synthesis: Serves as a precursor in the development of new pesticides and herbicides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis services catering to pharmaceutical and biotechnology clients.
• Academic Research: Employed in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	5-Fluoro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline
CAS No.	1203686-29-6
Molecular Formula	C11H14FN
Molecular Weight	179.24 g/mol
Synonyms	5-Fluoro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline; 4,4-Dimethyl-5-fluoro-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-5-fluoro-4,4-dimethylisoquinoline; 5-Fluoro-4,4-dimethyl-3,4-dihydro-1H-isoquinoline; 1203686-29-6; 5-F-4,4-DM-THIQ
EINECS	Contact for details

Quality Control

Our 5-Fluoro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.