Description

4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline-6-Carbonitrile Hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block. This compound is valued for its role as a key synthetic precursor in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily required by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for process development and scale-up.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of new pesticides and herbicides due to its heterocyclic core structure.
• Organic Synthesis: Serves as a versatile precursor for constructing more complex nitrogen-containing heterocycles in academic and industrial R&D.
• Chemical Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in analytical laboratories.
• Material Science: Investigated as a monomer or precursor for specialty polymers and functional materials.

Basic Information

Product Name	4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline-6-Carbonitrile Hydrochloride
CAS No.	1203686-13-8
Molecular Formula	C₁₂H₁₅ClN₂
Molecular Weight	222.71 g/mol
Synonyms	4,4-Dimethyl-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile hydrochloride; 6-Cyano-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; 4,4-Dimethyl-6-cyano-1,2,3,4-tetrahydroisoquinoline HCl; 1,2,3,4-Tetrahydro-4,4-dimethyl-6-isoquinolinecarbonitrile hydrochloride; THIQ-6-CN derivative
EINECS	Contact for details

Quality Control

Our 4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline-6-Carbonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.