Description

6-Bromo-4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline is a high-value, synthetically versatile brominated heterocyclic building block. This compound is critical for medicinal chemistry research and pharmaceutical development, serving as a key intermediate in the synthesis of complex molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel active compounds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization campaigns due to its reactive bromine atom and rigid tetrahydroisoquinoline scaffold.
• Agrochemical Synthesis: Serves as a building block for developing novel active ingredients in crop protection and pest management products.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and advanced materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Buchwald-Hartwig) to introduce diverse functional groups.
• Library Synthesis for High-Throughput Screening: Used to generate focused chemical libraries for biological screening against various disease targets.

Basic Information

Item	Details
Product Name	6-Bromo-4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1203686-06-9
Molecular Formula	C11H14BrN
Molecular Weight	240.14 g/mol
Synonyms	6-Bromo-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline; 4,4-Dimethyl-6-bromo-1,2,3,4-tetrahydroisoquinoline; 6-Bromo-4,4-dimethyl-3,4-dihydro-1H-isoquinoline; 1,2,3,4-Tetrahydro-6-bromo-4,4-dimethylisoquinoline; 6-Bromo-4,4-dimethyl-THIQ
EINECS	Contact for details

Quality Control

Our 6-Bromo-4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) with full analytical data are provided for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.