Description

5'-Fluoro-2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline] Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic and fluorinated molecular architecture. This compound is of significant value in medicinal chemistry research and development, particularly for its potential role in modulating biological targets. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, where precise chemical structure and reliable purity are paramount for successful outcomes.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates, especially within central nervous system (CNS) and oncology therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorination and spirocyclic motifs on potency, selectivity, and metabolic stability.
• Preclinical Development: Serves as a critical material for producing batches of lead compounds required for pharmacological and toxicological evaluation.
• Chemical Biology Probes: Utilized in the development of tool compounds for investigating specific enzyme or receptor functions in biological systems.
• Process Chemistry: Employed in route scouting and optimization for the scalable synthesis of complex active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development pipelines for global clients.

Basic Information

Product Name	5'-Fluoro-2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline] Hydrochloride
CAS No.	1203684-97-2
Molecular Formula	C12H13ClFN
Molecular Weight	225.69 g/mol
Synonyms	1'H-Spiro[cyclopropane-1,4'-isoquinoline], 5'-fluoro-2',3'-dihydro-, hydrochloride (1:1); 5'-Fluoro-2',3'-dihydrospiro[cyclopropane-1,4'-isoquinoline] hydrochloride; Spiro[cyclopropane-1,4'-isoquinoline], 5'-fluoro-2',3'-dihydro-, hydrochloride; 1203684-97-2; 5-Fluoro-2,3-dihydro-1H-spiro[cyclopropane-1,4-isoquinoline] hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 5'-Fluoro-2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline] Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure it meets stringent purity and identity specifications. Our quality assurance protocol is designed to support cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical quality attributes is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere or with desiccant for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.