Description

8-Fluoro-4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is a high-purity, fluorinated tetrahydroisoquinoline derivative, a key building block in advanced pharmaceutical research and development. This compound matters for its role as a versatile synthetic intermediate, enabling the creation of novel molecules with potential therapeutic applications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for drug discovery programs and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Agrochemical Development: Serves as a building block for creating new active ingredients in crop protection products.
• Chemical Biology Probes: Utilized in the development of fluorescent or affinity probes to study biological targets and pathways.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	8-Fluoro-4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
CAS No.	1203684-76-7
Molecular Formula	C11H15ClFN
Molecular Weight	215.70 g/mol
Synonyms	8-Fluoro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline HCl; 8-Fluoro-4,4-dimethyl-3,4-dihydro-1H-isoquinoline hydrochloride; 1,2,3,4-Tetrahydro-8-fluoro-4,4-dimethylisoquinoline hydrochloride; 4,4-Dimethyl-8-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride; 8-Fluoro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline monohydrochloride
EINECS	Contact for details

Quality Control

Our 8-Fluoro-4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.