Description

4,4-Dimethyl-6-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline is a high-value, fluorinated tetrahydroisoquinoline derivative, a privileged scaffold in modern organic synthesis. This compound matters as a sophisticated pharmaceutical intermediate and key building block for the development of novel bioactive molecules, leveraging the unique properties of the trifluoromethyl group. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate fluorine into complex heterocyclic systems.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets and kinase inhibitors.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Acts as a building block for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Investigated as a monomer or additive for specialty polymers and advanced organic electronic materials due to its fluorinated aromatic system.
• Chemical Biology Probe: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	4,4-Dimethyl-6-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1203684-72-3
Molecular Formula	C12H14F3N
Molecular Weight	229.24 g/mol
Synonyms	6-(Trifluoromethyl)-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline; 4,4-Dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-4,4-dimethyl-6-(trifluoromethyl)isoquinoline; 4,4-Dimethyl-6-(trifluoromethyl)-3,4-dihydro-1H-isoquinoline; 6-(Trifluoromethyl)-4,4-dimethyl-3,4-dihydro-1H-isoquinoline
EINECS	Contact for details

Quality Control

Our 4,4-Dimethyl-6-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline is produced under a strict quality management system. Each batch undergoes comprehensive analytical characterization including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as assay and impurity profiles. Our quality commitment supports compliance with cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.