Description

6,8-Difluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is a high-purity fluorinated heterocyclic building block essential for modern pharmaceutical and agrochemical research. Its core value lies in its role as a key synthetic intermediate, enabling the introduction of the difluorinated tetrahydroisoquinoline scaffold into target molecules to modulate their biological activity and physicochemical properties. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the fluorine atoms can enhance metabolic stability and bioavailability.
• Chemical Biology: Serves as a versatile scaffold for creating molecular probes and tool compounds to study biological pathways.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by providing a fluorinated core for analog generation.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for complex molecules in pilot plant and manufacturing settings.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development programs for global clients.

Basic Information

Product Name	6,8-Difluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
CAS No.	1203684-62-1
Molecular Formula	C9H8F2N·HCl
Molecular Weight	203.62 g/mol (Free base: 167.16 g/mol)
Synonyms	6,8-Difluoro-3,4-dihydro-1H-isoquinoline Hydrochloride; 6,8-Difluoro-1,2,3,4-tetrahydroisoquinoline HCl; 6,8-Difluoro-1,2,3,4-tetrahydroisoquinoline Hydrochloride Salt; 6,8-Difluoro-THIQ·HCl; 6,8-F2-THIQ Hydrochloride; 1,2,3,4-Tetrahydro-6,8-difluoro-isoquinoline Hydrochloride; 6,8-Difluoro-1,2,3,4-tetrahydroisoquinoline monohydrochloride
EINECS	Contact for details

Quality Control

Our 6,8-Difluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.