Description

4,4-Dimethyl-7-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is a high-purity, advanced pharmaceutical intermediate and versatile organic building block. This compound is critical for research and development in medicinal chemistry, particularly for introducing the trifluoromethyl group into complex molecular scaffolds. It is primarily needed by pharmaceutical R&D laboratories, agrochemical manufacturers, and fine chemical synthesis specialists for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique trifluoromethylated tetrahydroisoquinoline core.
• Agrochemical Synthesis: Intermediate for developing advanced pesticides and herbicides where the CF3 group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Fluorine Chemistry Studies: A valuable compound for investigating the effects of fluorine substitution on pharmacokinetic properties like metabolic stability and lipophilicity.
• Fine Chemical Production: Used in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	4,4-Dimethyl-7-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
CAS No.	1203683-03-7
Molecular Formula	C12H14F3N·HCl
Molecular Weight	265.70 g/mol
Synonyms	7-(Trifluoromethyl)-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; 4,4-Dimethyl-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline HCl; 1,2,3,4-Tetrahydro-4,4-dimethyl-7-(trifluoromethyl)isoquinoline hydrochloride; 4,4-Dimethyl-7-(trifluoromethyl)-3,4-dihydro-1H-isoquinoline hydrochloride; 7-Trifluoromethyl-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
EINECS	Contact for details

Quality Control

Our 4,4-Dimethyl-7-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.