Description

2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-6'-Carbonitrile Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and isoquinoline-based molecular architecture. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block in the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new drug candidates, particularly in areas such as central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• CNS Drug Development: Employed in the synthesis of potential therapeutic compounds targeting neurological disorders.
• Oncology Research: Serves as a building block for novel small-molecule inhibitors and targeted cancer therapies.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Process Chemistry: Used in route scouting and scale-up studies for the commercial manufacturing of complex drug molecules.

Basic Information

Item	Details
Product Name	2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-6'-Carbonitrile Hydrochloride
CAS No.	1203682-92-1
Molecular Formula	C13H13ClN2
Molecular Weight	232.71 g/mol
Synonyms	6'-Cyano-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline] hydrochloride; 1'H-Spiro[cyclopropane-1,4'-isoquinoline]-6'-carbonitrile, 2',3'-dihydro-, hydrochloride; Spiro[cyclopropane-1,4'-isoquinoline]-6'-carbonitrile, 2',3'-dihydro-1'H-, hydrochloride; CAS 1203682-92-1
EINECS	Contact for details

Quality Control

Our 2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-6'-Carbonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure full traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under a dry inert atmosphere for long-term storage to maintain stability and purity. Recommended storage temperature is 2-8°C for prolonged periods.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.