Description

Methyl 4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular research. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in innovative drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting neurological and cardiovascular pathways.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing tetrahydroisoquinoline scaffolds, a privileged structure in drug design.
• Research & Development (R&D): Essential for academic and industrial research focused on developing new therapeutic agents and studying structure-activity relationships (SAR).
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under cGMP conditions for clinical trial material production.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Methyl 4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylate
CAS No.	1203682-73-8
Molecular Formula	C13H17NO2
Molecular Weight	219.28 g/mol
Synonyms	Methyl 4,4-dimethyl-1,2,3,4-tetrahydro-6-isoquinolinecarboxylate; 6-Carbomethoxy-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline; 4,4-Dimethyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid methyl ester; 1203682-73-8; Methyl 4,4-dimethyl-3,4-dihydro-1H-isoquinoline-6-carboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, and our quality systems support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.