Description

4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline-5-Carbonitrile Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1203682-69-2. This compound is a critical building block in the synthesis of complex organic molecules, valued for its defined stereochemistry and reactive functional groups. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its tetrahydroisoquinoline scaffold.
• Chemical Synthesis Building Block: Serves as a versatile synthon for constructing more complex heterocyclic compounds in medicinal chemistry.
• Academic & R&D Laboratories: Employed in methodological studies and for creating specialized compound libraries for high-throughput screening.
• Process Chemistry Development: Used for scaling up synthetic routes and optimizing manufacturing processes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline-5-Carbonitrile Hydrochloride
CAS No.	1203682-69-2
Molecular Formula	C12H15ClN2
Molecular Weight	222.71 g/mol
Synonyms	4,4-Dimethyl-1,2,3,4-tetrahydro-5-isoquinolinecarbonitrile hydrochloride; 5-Cyano-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; 4,4-Dimethyl-5-cyano-1,2,3,4-tetrahydroisoquinoline HCl; 1203682-69-2; DTQI-5-CN HCl
EINECS	Contact for details

Quality Control

Our 4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline-5-Carbonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.