Description

8-Bromo-4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline is a high-value, synthetically versatile brominated heterocyclic building block. This compound is critical for medicinal chemistry research and pharmaceutical development, serving as a key intermediate for constructing complex molecular architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) targets and kinase inhibitors.
• Medicinal Chemistry Scaffold: Used in structure-activity relationship (SAR) studies and library synthesis due to its rigid, substituted tetrahydroisoquinoline core.
• Agrochemical Research: Serves as a building block for developing new active ingredients with potential herbicidal or insecticidal properties.
• Ligand and Catalyst Development: The bromine atom allows for further functionalization via cross-coupling reactions, making it useful for creating specialized ligands.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and protein function.
• Advanced Material Synthesis: A potential monomer or intermediate for creating organic electronic materials or specialty polymers.

Basic Information

Product Name	8-Bromo-4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1203682-59-0
Molecular Formula	C11H14BrN
Molecular Weight	240.14 g/mol
Synonyms	8-Bromo-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline; 4,4-Dimethyl-8-bromo-1,2,3,4-tetrahydroisoquinoline; 8-Bromo-4,4-dimethyl-3,4-dihydro-1H-isoquinoline; 1,2,3,4-Tetrahydro-8-bromo-4,4-dimethylisoquinoline; 8-Bromo-4,4-dimethyl-THIQ; 8-Br-4,4-diMe-THIQ
EINECS	Contact for details

Quality Control

Our 8-Bromo-4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided with every shipment. We support cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.