Description

4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline-7-Carbonitrile Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1203682-40-9. This compound is a critical building block in the synthesis of complex organic molecules, offering a defined stereochemical center and functional groups essential for modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Used in the preparation of complex tetrahydroisoquinoline derivatives and other nitrogen-containing heterocycles.
• Academic & Industrial R&D: Employed in laboratories for developing new synthetic methodologies and exploring novel chemical entities.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline-7-Carbonitrile Hydrochloride
CAS No.	1203682-40-9
Molecular Formula	C12H15ClN2
Molecular Weight	222.71 g/mol
Synonyms	7-Cyano-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; 4,4-Dimethyl-1,2,3,4-tetrahydro-7-isoquinolinecarbonitrile hydrochloride; 4,4-Dimethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline HCl; 4,4-Dimethyl-1,2,3,4-tetrahydroisoquinoline-7-carbonitrile HCl; 1203682-40-9; DTQ-7-CN HCl
EINECS	Contact for details

Quality Control

Our 4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline-7-Carbonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with client specifications and current Good Manufacturing Practice (cGMP) principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.