Description

1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-3-Iodo-1-(Phenylsulfonyl)- is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because its unique halogenated pyrrolopyridine core, protected by a phenylsulfonyl group, provides a versatile scaffold for constructing complex molecular architectures, particularly in pharmaceutical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Agrochemical Research: Used in the development of novel herbicides and fungicides due to its bioactive heterocyclic structure.
• Material Science: Acts as a building block for organic semiconductors and light-emitting materials.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions.
• Medicinal Chemistry SAR Studies: Utilized for structure-activity relationship exploration to optimize drug candidate potency and selectivity.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-3-Iodo-1-(Phenylsulfonyl)-
CAS No.	1203566-61-3
Molecular Formula	C13H8ClIN2O2S
Molecular Weight	418.63 g/mol
Synonyms	4-Chloro-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-(Benzenesulfonyl)-4-chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine 1-(phenylsulfonyl) derivative; 7-Azaindole, 4-chloro-3-iodo-1-(phenylsulfonyl)-; 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-3-iodo-1-(phenylsulfonyl)-; 4-Chloro-3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine (common misnomer); 1203566-61-3
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-3-Iodo-1-(Phenylsulfonyl)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a desiccator to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.