Description

L-2-Aminopentanoic-4,4,5,5,5-D5 Acid is a deuterium-labeled derivative of the essential amino acid L-norvaline, featuring five deuterium atoms at specific positions. This high-purity, isotopically enriched compound is critical for advanced research and development, providing a stable, non-radioactive tracer for precise metabolic and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug discovery, proteomics, and metabolic pathway analysis.

Application

• Internal Standard in Mass Spectrometry: Serves as a crucial quantitative standard in LC-MS and GC-MS analyses for accurate measurement of endogenous norvaline or related compounds.
• Drug Metabolism and Pharmacokinetics (DMPK): Used as a stable isotope-labeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) profiles of new chemical entities.
• Proteomics and Metabolic Research: Enables tracking and quantification of amino acid incorporation and turnover in complex biological systems.
• Pharmaceutical Impurity Profiling: Aids in the identification and characterization of process-related impurities and degradants in active pharmaceutical ingredients (APIs).
• Biochemical Pathway Elucidation: Facilitates research into amino acid metabolism, enzyme mechanisms, and related disorders.
• Synthesis of Labeled Peptides/Proteins: Acts as a building block for the synthesis of deuterium-labeled peptides for structural and functional studies.

Basic Information

Product Name	L-2-Aminopentanoic-4,4,5,5,5-D5 Acid
CAS No.	1202936-50-2
Molecular Formula	C5H4D5NO2
Molecular Weight	122.16 g/mol
Synonyms	L-Norvaline-4,4,5,5,5-d5; (2S)-2-Aminopentanoic-4,4,5,5,5-d5 Acid; Deuterated L-Norvaline; L-2-Aminovaleric-4,4,5,5,5-d5 Acid; (S)-2-Aminopentanoic-d5 Acid; L-Norvaline-d5; Stable Isotope Labeled L-Norvaline
EINECS	Contact for details

Quality Control

Our L-2-Aminopentanoic-4,4,5,5,5-D5 Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic enrichment (by MS), optical rotation, and residual solvent content. We support compliance with cGMP and ICH guidelines for advanced research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Optical Rotation	[α]20/D: +19.0° to +23.0° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.