Description

L-Threonine-2,3-D2 is a stable isotope-labeled derivative of the essential amino acid L-Threonine, specifically deuterated at the 2 and 3 positions. This high-purity compound is critical for advanced research and development applications where precise molecular tracking and quantification are required. It is primarily utilized by pharmaceutical, biotechnology, and academic research institutions engaged in metabolic studies, proteomics, and the development of novel diagnostic agents.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a crucial quantitative reference in LC-MS and GC-MS analysis for accurate measurement of endogenous L-Threonine levels in complex biological matrices.
• Metabolic Pathway Tracing: Used in deuterium-labeling studies to investigate amino acid metabolism, protein synthesis rates, and metabolic flux in cell cultures, animal models, and clinical research.
• Proteomics & Biomarker Discovery: Enables precise relative and absolute quantification (AQUA) in targeted proteomic workflows for biomarker validation and protein expression profiling.
• Pharmaceutical R&D: Employed in the development and pharmacokinetic (PK) studies of new drug candidates, particularly those targeting amino acid pathways or requiring stable isotope tracers.
• Nutritional Science Research: Facilitates studies on protein metabolism, amino acid requirements, and the metabolic fate of dietary components in nutritional interventions.
• NMR Spectroscopy: Acts as a valuable tool in Nuclear Magnetic Resonance (NMR) spectroscopy for structural elucidation and dynamic studies of biomolecules.

Basic Information

Product Name	L-Threonine-2,3-D2
CAS No.	1202936-45-5
Molecular Formula	C4H7D2NO3
Molecular Weight	121.14 g/mol
Synonyms	(2S,3R)-2-Amino-3-hydroxybutanoic-2,3-d2 acid; L-Threonine-d2 (2,3-D2); (2S,3R)-2-Amino-3-hydroxybutyric-2,3-d2 acid; Threonine-2,3-d2; (2S,3R)-Threonine-2,3-d2; Deuterated L-Threonine; L-Threonine (2,3-d2); Stable Isotope Labeled L-Threonine
EINECS	Contact for details

Quality Control

Our L-Threonine-2,3-D2 is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity, meeting the stringent requirements of analytical and research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity (by HPLC), chiral purity, and residual solvent content. We adhere to relevant industry standards for high-purity fine chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chiral Purity	≥ 99.0% L-isomer
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.