Description

Atenolol-D7 is a deuterium-labeled analog of the widely used β-blocker Atenolol, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, particularly in pharmacokinetic and metabolism studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities engaged in drug development and bioanalytical research.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry for the precise measurement of Atenolol in biological matrices (plasma, serum, urine).
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Used to develop, optimize, and validate robust analytical methods compliant with FDA, EMA, and ICH guidelines.
• Drug Impurity & Degradation Profiling: Assists in the identification and quantification of related substances and degradation products in drug substances and products.
• Forensic & Clinical Toxicology: Supports accurate quantification in forensic analysis and therapeutic drug monitoring (TDM) programs.
• Stable Isotope Dilution Assays (SIDA): Serves as the labeled component in high-precision assays to minimize matrix effects and improve data reproducibility.

Basic Information

Product Name	Atenolol-D7
CAS No.	1202864-50-3
Molecular Formula	C14H15D7N2O3
Molecular Weight	269.36 g/mol
Synonyms	2-[4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetamide-d7; Atenolol (phenyl-d7); Atenolol-d7; [phenyl-d7]-Atenolol; 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide-d7; (±)-Atenolol-d7; DL-Atenolol-d7
EINECS	Contact for details

Quality Control

Every batch of Atenolol-D7 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity to meet the exacting demands of analytical reference standards. Comprehensive testing includes assay, isotopic enrichment (D7), and identification of any unlabeled impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting lot-specific results for traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D (D7)
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.