Description

D-4-Hydroxyphenylalanine-3,3-D2 is a deuterium-labeled isotopologue of the amino acid L-DOPA, a critical biochemical precursor. This compound is specifically designed for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in analytical measurements by correcting for instrument variability and matrix effects. It is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors who require precise quantification of neurotransmitters, metabolites, and related compounds.

Application

• Mass Spectrometry Internal Standard: Primary use as a stable isotope-labeled internal standard (SIL-IS) for the accurate quantification of L-DOPA, dopamine, and related catecholamines in LC-MS/MS and GC-MS applications.
• Pharmacokinetic & Metabolic Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) for pharmaceuticals targeting neurological pathways.
• Clinical Diagnostics: Used in the development and validation of high-precision assays for neurological disorders, such as Parkinson's disease, by measuring biomarkers in biological fluids.
• Biochemical Research: Serves as a tracer in metabolic pathway analysis and enzymology studies to investigate tyrosine and phenylalanine metabolism.
• Pharmaceutical Quality Control: Critical for the assay and impurity profiling of L-DOPA active pharmaceutical ingredients (APIs) and finished drug products to ensure potency and safety.
• Forensic & Doping Control Analysis: Supports the accurate identification and quantification of banned substances or endogenous compounds in forensic toxicology and anti-doping programs.

Basic Information

Product Name	D-4-Hydroxyphenylalanine-3,3-D2
CAS No.	1202064-22-9
Molecular Formula	C9H9D2NO4
Molecular Weight	199.20 g/mol (for C9H9D2NO4)
Synonyms	D-4-Hydroxyphenyl-d2-alanine; (R)-2-Amino-3-(4-hydroxyphenyl)-3,3-d2-propanoic acid; D-DOPA-3,3-d2; D-3,3-Dideutero-4-hydroxyphenylalanine; Deuterated D-DOPA; D-3-(3,3-Dideutero-4-hydroxyphenyl)alanine; (R)-3,3-Dideutero-4-hydroxyphenylalanine; D-4-Hydroxy-d2-phenylalanine
EINECS	Contact for details

Quality Control

Every batch of D-4-Hydroxyphenylalanine-3,3-D2 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments, including isotopic purity (D-enrichment) and chemical purity verified by advanced chromatographic and spectroscopic techniques. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting identity, assay, impurity profile, and isotopic enrichment to meet the stringent requirements of research and quality control laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.