Description

D-Alanine-2,3,3,3-D4 CAS NO 1202063-27-1 is a high-purity, isotopically labeled derivative of the non-essential amino acid D-alanine, where four hydrogen atoms are replaced with deuterium at specific positions. This compound is a critical tool in advanced research, enabling precise metabolic and pharmacokinetic studies through mass spectrometry and NMR spectroscopy. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and analytical laboratories focused on proteomics, metabolic pathway analysis, and the development of novel therapeutics.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of endogenous alanine and related metabolites.
• Metabolic Pathway Tracing: Used in stable isotope labeling studies to investigate amino acid metabolism, protein synthesis rates, and metabolic flux in biological systems.
• Pharmaceutical Research & Drug Development: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the fate of drug candidates containing alanine moieties.
• NMR Spectroscopy: Acts as a deuterated probe in nuclear magnetic resonance studies to simplify complex spectra and elucidate molecular structure and dynamics.
• Biochemical Research: Utilized in enzymatic studies, particularly those involving D-amino acid oxidase or racemases, to understand enzyme kinetics and mechanisms.
• Proteomics and Biomarker Discovery: Facilitates accurate quantification in peptide and protein analysis, aiding in the identification of disease biomarkers.

Basic Information

Product Name	D-Alanine-2,3,3,3-D4
CAS No.	1202063-27-1
Molecular Formula	C₃H₃D₄NO₂
Molecular Weight	93.11 g/mol (for deuterated form)
Synonyms	(2R)-2-Aminopropanoic-2,3,3,3-d4 Acid; D-α-Alanine-2,3,3,3-d4; Deuterated D-Alanine; D-Alanine-d4; (R)-Alanine-2,3,3,3-d4; D-2-Aminopropionic Acid-d4; (R)-2-Aminopropanoic Acid-d4; D-Ala-d4
EINECS	Contact for details

Quality Control

Every batch of D-Alanine-2,3,3,3-D4 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including chiral purity to ensure the D-isomer configuration. Certificates of Analysis (COA) are provided with each shipment, detailing results for assay, isotopic enrichment, chiral purity, and impurity profiles. Our quality commitment supports compliance with the rigorous standards required for research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.