Description

L-Anserine-D4 (n-β-Alanyl-D4) is a deuterium-labeled isotopologue of the naturally occurring dipeptide L-anserine, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity compound is essential for ensuring accuracy and precision in mass spectrometry-based analyses, eliminating matrix effects and correcting for analyte loss during sample preparation. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, nutritional supplement, and clinical diagnostics industries who require definitive quantification of L-anserine and related metabolites.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a stable isotope-labeled internal standard for the precise and accurate quantification of endogenous L-anserine in complex biological matrices such as plasma, serum, urine, and tissue homogenates.
• Pharmacokinetic and Metabolic Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) research to track the fate of L-anserine and its role in carnosine metabolism within physiological systems.
• Nutritional Science and Sports Medicine Research: Enables reliable measurement of L-anserine levels in studies investigating its potential ergogenic, antioxidant, or neuroprotective effects in dietary supplements and functional foods.
• Clinical Diagnostics Development: Facilitates the development of robust clinical assays for measuring L-anserine as a potential biomarker for certain muscular, neurological, or metabolic conditions.
• Method Validation and Quality Control: Critical for validating analytical methods according to ICH, FDA, or other regulatory guidelines, ensuring method robustness, accuracy, and reproducibility in GLP/GMP environments.
• Isotope Dilution Analysis: Employed in high-accuracy analytical techniques where the deuterated standard is used to spike samples before analysis to correct for recovery and instrument variability.

Basic Information

Item	Detail
Product Name	L-Anserine-D4 (n-β-Alanyl-D4)
CAS No.	1201658-81-2
Molecular Formula	C10H12D4N4O3
Molecular Weight	228.27 g/mol (approx.)
Synonyms	L-Anserine-d4; (2S)-2-[[(3S)-3-Amino-1-(deuteriomethyl)-1-oxidanylidene-propyl]amino]-3-(1H-imidazol-5-yl)propanoic acid; β-Alanyl-D4-L-1-methylhistidine; Deuterated L-Anserine; L-Anserine (methyl-d4); Anserine Internal Standard; Isotope-labeled Anserine
EINECS	Contact for details

Quality Control

Every batch of L-Anserine-D4 is manufactured and analyzed under strict quality systems to ensure the highest standards of isotopic purity and chemical identity required for analytical applications. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing critical parameters such as isotopic enrichment (D-content), chemical purity by HPLC, and spectroscopic confirmation. Our quality commitment supports research requiring reliable and traceable reference standards for regulatory submission and publication.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.