Description

1'-Benzyl 1-tert-Butyl 5-Fluorospiro[Indoline-3,4'-Piperidine]-1,1'-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of next-generation therapeutics. The product, identified by CAS number 1201649-36-6, is supplied under stringent quality controls to ensure batch-to-batch consistency for critical synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Development: Integral in the process development and scale-up of new active pharmaceutical ingredients, particularly for CNS disorders.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Biochemical Tool Compound: May be used in biochemical assays to study specific enzyme or receptor interactions due to its spiro[indoline-3,4'-piperidine] core.
• Academic Research: Employed in university and institutional labs for synthetic methodology development and pharmacological studies.

Basic Information

Product Name	1'-Benzyl 1-tert-Butyl 5-Fluorospiro[Indoline-3,4'-Piperidine]-1,1'-Dicarboxylate
CAS No.	1201649-36-6
Molecular Formula	C26H31FN2O4
Molecular Weight	454.54 g/mol
Synonyms	5-Fluoro-1'-benzyl 1-tert-butyl spiro[indoline-3,4'-piperidine]-1,1'-dicarboxylate; 1-tert-Butyl 1'-benzyl 5-fluorospiro[indoline-3,4'-piperidine]-1,1'-dicarboxylate; 1,1'-Dicarboxylic acid, 1-(1,1-dimethylethyl) 1'-(phenylmethyl) 5-fluoro-3,4-dihydrospiro[2H-indole-2,4'-piperidine] ester; 5-Fluoro-spiro[indoline-3,4'-piperidine]-1,1'-dicarboxylic acid 1-tert-butyl ester 1'-benzyl ester; BOC-Spiro Indoline Piperidine Fluorobenzyl Ester; tert-Butyl 1'-benzyl 5-fluoro-1,3-dihydrospiro[indene-2,4'-piperidine]-1-carboxylate 1'-carboxylate (related structure).
EINECS	Contact for details

Quality Control

Our 1'-Benzyl 1-tert-Butyl 5-Fluorospiro[Indoline-3,4'-Piperidine]-1,1'-Dicarboxylate is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for pharmaceutical R&D. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material suitable for research use under non-GMP conditions or support development toward cGMP-grade material for advanced clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.