Description

tert-Butyl 5-Oxo-4,7-diazaspiro[2.5]octane-7-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is of significant value in medicinal chemistry for constructing complex molecular architectures, particularly in the development of novel therapeutic agents. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of bioactive molecules, including protease inhibitors and other small-molecule drugs targeting the central nervous system and oncology.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing constrained spirocyclic motifs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve drug-like properties.
• Protease Inhibitor Development: Serves as a core scaffold for the design and synthesis of potential protease inhibitors due to its diazaspiro structure.
• CNS Drug Discovery: Applied in research programs targeting central nervous system disorders, where the spirocycle can enhance blood-brain barrier penetration and receptor binding.
• Oncology Research: Utilized in the construction of candidate molecules for cancer therapy, leveraging its ability to impart conformational rigidity.
• Chemical Biology: Acts as a versatile probe or precursor for labeling studies and the development of chemical tools.

Basic Information

Product Name	tert-Butyl 5-Oxo-4,7-diazaspiro[2.5]octane-7-carboxylate
CAS No.	1199794-51-8
Molecular Formula	C11H18N2O3
Molecular Weight	226.27 g/mol
Synonyms	7-Boc-5-oxo-4,7-diazaspiro[2.5]octane; tert-Butyl 5-oxo-4,7-diazaspiro[2.5]octane-7-carboxylate; 4,7-Diazaspiro[2.5]octane-7-carboxylic acid, 5-oxo-, 1,1-dimethylethyl ester; 5-Oxo-4,7-diazaspiro[2.5]octane-7-carboxylic acid tert-butyl ester; Boc-4,7-diazaspiro[2.5]octan-5-one; 1199794-51-8
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Oxo-4,7-diazaspiro[2.5]octane-7-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with the standards expected for pharmaceutical R&D and cGMP intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.