Description

5-Bromothiazole-2-Carbonitrile is a high-purity, versatile heterocyclic building block essential for advanced organic synthesis. Its unique molecular structure, featuring both bromine and nitrile functional groups on a thiazole core, makes it a critical intermediate for constructing complex molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides with specific modes of action.
• Material Science Precursor: Serves as a building block for functional polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probe: Employed in the synthesis of molecular probes and tags for studying biological systems and protein interactions.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nitrile Transformation: The cyano group can be hydrolyzed to carboxylic acids, reduced to amines, or used to form heterocycles like tetrazoles.

Basic Information

Product Name	5-Bromothiazole-2-Carbonitrile
CAS No.	1198154-99-2
Molecular Formula	C4HBrN2S
Molecular Weight	189.03 g/mol
Synonyms	2-Cyano-5-bromothiazole; 5-Bromo-2-thiazolecarbonitrile; 5-Bromothiazole-2-carbonitrile; 5-Bromo-1,3-thiazole-2-carbonitrile; 5-Bromothiazol-2-yl cyanide; 2-Bromo-5-cyanothiazole; Thiazole, 5-bromo-2-cyano-; 1198154-99-2
EINECS	Contact for details

Quality Control

Our 5-Bromothiazole-2-Carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ISO 9001 standards for pharmaceutical and industrial applications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive and should be stored away from light. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.