Description

1H-Indazole, 4-Bromo-6-(Difluoromethoxy)- is a high-purity, advanced pharmaceutical intermediate and versatile heterocyclic building block. Its unique bromo- and difluoromethoxy-substituted indazole core makes it a critical synthon for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs). This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate complex, fluorinated heterocycles into new molecular entities.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, particularly in oncology, CNS, and anti-inflammatory therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its halogen and fluorine substituents, which can modulate potency, metabolic stability, and bioavailability.
• Agrochemical Synthesis: Serves as a precursor for developing novel herbicides, fungicides, and insecticides that leverage the indazole scaffold.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Material Science: Potential monomer or precursor for creating specialized polymers and organic electronic materials with unique properties.

Basic Information

Product Name	1H-Indazole, 4-Bromo-6-(Difluoromethoxy)-
CAS No.	1196875-83-8
Molecular Formula	C8H5BrF2N2O
Molecular Weight	263.04 g/mol
Synonyms	4-Bromo-6-(difluoromethoxy)-1H-indazole; 4-Bromo-6-(difluoromethoxy)indazole; 6-(Difluoromethoxy)-4-bromo-1H-indazole; 1H-Indazole, 4-bromo-6-(difluoromethoxy)-; 1196875-83-8; 4-Bromo-6-difluoromethoxy-1H-indazole; 4-Bromo-6-(difluoromethoxy)-1H-indazole (CAS 1196875-83-8)
EINECS	Contact for details

Quality Control

Our 1H-Indazole, 4-Bromo-6-(Difluoromethoxy)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and internal quality standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.