Description

Methyl 2-{4-[(3S)-1-(tert-Butoxycarbonyl)Piperidin-3-Yl]-Phenyl}-2H-Indazole-7-Carboxylate CAS NO 1196713-67-3 is a high-purity, advanced pharmaceutical intermediate featuring a complex, multi-ring heterocyclic structure. This compound is of significant value for its role as a critical building block in the synthesis of novel, targeted therapeutic agents, particularly in oncology and immunology research. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex active pharmaceutical ingredients (APIs) for investigational new drugs.
• Oncology Research: Used in the development of kinase inhibitors and other targeted cancer therapies due to its indazole and piperidine motifs.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry: Employed in route scouting and scale-up studies for the commercial manufacturing of specialty pharmaceuticals.
• Bioconjugation & Probe Development: The reactive ester group and protected amine make it suitable for creating labeled compounds for biochemical assays.

Basic Information

Product Name	Methyl 2-{4-[(3S)-1-(tert-Butoxycarbonyl)Piperidin-3-Yl]-Phenyl}-2H-Indazole-7-Carboxylate
CAS No.	1196713-67-3
Molecular Formula	C26H29N3O4
Molecular Weight	447.53 g/mol
Synonyms	Methyl 2-[4-[(3S)-1-[(1,1-Dimethylethoxy)carbonyl]-3-piperidinyl]phenyl]-2H-indazole-7-carboxylate; (S)-Methyl 2-(4-(1-(tert-butoxycarbonyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxylate; Boc-Protected Indazole-Piperidine Intermediate; 7-Carbomethoxy-2-[4-((S)-3-Boc-piperidinyl)phenyl]-2H-indazole; 1196713-67-3; Indazole-7-carboxylic acid, 2-[4-[(3S)-1-[(1,1-dimethylethoxy)carbonyl]-3-piperidinyl]phenyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-{4-[(3S)-1-(tert-Butoxycarbonyl)Piperidin-3-Yl]-Phenyl}-2H-Indazole-7-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral HPLC for enantiomeric excess, and NMR/IR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full analytical data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.