Description

Pyrido[3,4-D]Pyrimidine-7(6H)-Carboxylic Acid, 2-Chloro-5,8-Dihydro-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern medicinal chemistry. This compound serves as a critical building block in the synthesis of complex heterocyclic molecules, enabling the development of novel therapeutic agents. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug candidates.
• Chemical Synthesis: Serves as a versatile scaffold for constructing complex pyrido[3,4-d]pyrimidine derivatives with potential biological activity.
• Biochemical Research: Employed in the development of chemical probes and assay tools for studying enzyme function and signal transduction pathways.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.
• Academic Research: Utilized in university and institutional laboratories for exploratory synthetic chemistry and drug discovery programs.

Basic Information

Product Name	Pyrido[3,4-D]Pyrimidine-7(6H)-Carboxylic Acid, 2-Chloro-5,8-Dihydro-, 1,1-Dimethylethyl Ester
CAS No.	1196156-15-6
Molecular Formula	C14H16ClN3O2
Molecular Weight	293.75 g/mol
Synonyms	tert-Butyl 2-chloro-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate; 2-Chloro-5,8-dihydro-7H-pyrido[3,4-d]pyrimidine-7-carboxylic acid 1,1-dimethylethyl ester; 2-Chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester; 7-(tert-Butoxycarbonyl)-2-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; 2-Chloro-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; 2-Chloro-5,8-dihydro-7H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester; tert-Butyl 2-chloro-7,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxylate
EINECS	Contact for details

Quality Control

Our Pyrido[3,4-D]Pyrimidine-7(6H)-Carboxylic Acid, 2-Chloro-5,8-Dihydro-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.